Preparation of NIR absorbing axial substituted tin(iv) porphyrins and their photocytotoxic properties.

ABSTRACT: Sn(iv) porphyrins ([Sn(iv)TTP(3PyO)₂] (5) and [Sn(iv)TPP(3PyO)₂] (6) [tetrathienylporphyrin (TTP), tetraphenylporphyrin (TPP), and pyridyloxy (PyO)]) were prepared and characterized and their photocytotoxicity upon irradiation with 625 nm light has been studied. The presence of the 3PyO axial ligands was found to limit the aggregation and enhance the solubility of 5 and 6 in DMF/H₂O (1 : 1). The photophysical properties and photodynamic therapy (PDT) activity of the meso-2-thienyl and meso-phenyl-substituted Sn(iv) porphyrins are compared. 5 and 6 were found to be photocytotoxic in MCF-7 cancer cells when irradiated with a Thorlabs M625L3 LED at 625 nm but remained nontoxic in the dark. The PDT activit

SUBMITTER: Babu B 

PROVIDER: S-EPMC6349065 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature