Nitrogen Starvation Induces Persister Cell Formation in Escherichia coli.

ABSTRACT: To cope with fluctuations in their environment, bacteria have evolved multiple adaptive stress responses. One such response is the nitrogen regulation stress response, which allows bacteria, such as Escherichia coli, to cope with and overcome conditions of nitrogen limitation. This response is directed by the two-component system NtrBC, where NtrC acts as the major transcriptional regulator to activate the expression of genes to mount the response. Recently, my colleagues and I showed that NtrC directly regulates the expression of the relA gene, the major (p)ppGpp synthetase in E. coli, coupling the nitrogen regulation stress and stringent responses. As elevated levels of (p)ppGpp have been implicated in the formation of persister cells, here, I investigated whether ni

SUBMITTER: Brown DR 

PROVIDER: S-EPMC6349093 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature