Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin.

ABSTRACT: The cyanoacrylate compound phenamacril (also known as JS399-19) is a recently identified fungicide that exerts its antifungal effect on susceptible Fusarium species by inhibiting the ATPase activity of their myosin class I motor domains. Although much is known about the antifungal spectrum of phenamacril, the exact mechanism behind the phenamacril-mediated inhibition remains to be resolved. Here, we describe the characterization of the effect of phenamacril on purified myosin motor constructs from the model plant pathogen and phenamacril-susceptible species Fusarium graminearum, phenamacril-resistant Fusarium species, and the mycetozoan model organism Dictyostelium discoideum Our results show that phenamacril potently (IC₅₀ ∼360 nm), reversibly, and n

SUBMITTER: Wollenberg RD 

PROVIDER: S-EPMC6349130 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature