Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation.

ABSTRACT: Myocardial ischaemia is associated with an exacerbated inflammatory response, as well as with a deregulation of intercellular communication systems. Macrophages have been implicated in the maintenance of heart homeostasis and in the progression and resolution of the ischaemic injury. Nevertheless, the mechanisms underlying the crosstalk between cardiomyocytes and macrophages remain largely underexplored. Extracellular vesicles (EVs) have emerged as key players of cell-cell communication in cardiac health and disease. Hence, the main objective of this study was to characterize the impact of cardiomyocyte-derived EVs upon macrophage activation. Results obtained demonstrate that EVs released by H9c2 cells induced a pro-inflammatory profile in macrophages, via p38MAPK activation and increased

SUBMITTER: Almeida Paiva R 

PROVIDER: S-EPMC6349194 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature