Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3.

ABSTRACT: The concept of drug repositioning has recently received considerable attention in the field of oncology. In the present study, we propose that paroxetine can be used as a potent anticancer drug. Paroxetine, one of the selective serotonin reuptake inhibitors (SSRIs), has been widely prescribed for the treatment of depression and anxiety disorders. Recently, SSRIs have been reported to have anticancer activity in various types of cancer cells; however, the underlying mechanisms of their action are not yet known. In this study, we investigated the potential anticancer effect of paroxetine in human colorectal cancer cells, HCT116 and HT-29. Treatment with paroxetine reduced cell viability, which was associated with marked increase in apoptosis, in both the cell lines. Also, paroxetine effectiv

SUBMITTER: Jang WJ 

PROVIDER: S-EPMC6349215 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature