Allometric scaling of hepatic biotransformation in rainbow trout.

ABSTRACT: Biotransformation may substantially impact the toxicity and accumulation of xenobiotic chemicals in fish. However, this activity can vary substantially within and among species. In this study, liver S9 fractions from rainbow trout (4-400 g) were used to evaluate relationships between fish body mass and the activities of phase I and phase II metabolic enzymes. An analysis of log-transformed data, expressed per gram of liver (g liver^-1), showed that total cytochrome P450 (CYP) concentration, UDP-glucuronosyltransferase (UGT) activity, and glutathione S-transferase (GST) activity exhibited small but significant inverse relationships with fish body weight. In contrast, in vitro intrinsic clearance rates (CL_{IN VITRO,INT}) for three polycyclic aromatic hydrocarbons (PAHs) in

SUBMITTER: Fitzsimmons PN 

PROVIDER: S-EPMC6349251 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature