Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway.

ABSTRACT: The nematode Caenorhabditis elegans has been used to examine the influence of epicatechin (EC), an abundant flavonoid in the human diet, in some stress biomarkers (ROS production, lipid peroxidation and protein carbonylation). Furthermore, the ability of EC to modulate the expression of some key genes in the insulin/IGF-1 signaling pathway (IIS), involved in longevity and oxidative or heat shock stress response, has also been explored. The final aim was to contribute to the elucidation of the mechanisms involved in the biological effects of flavonoids. The results showed that EC-treated wild-type C. elegans exhibited increased survival and reduced oxidative damage of biomolecules when submitted to thermal stress. EC treatment led to a moderate elevation in ROS levels, which might activate

SUBMITTER: Ayuda-Duran B 

PROVIDER: S-EPMC6349306 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature