Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse.

ABSTRACT:

Background

A few days of bed rest or immobilization following injury, disease, or surgery can lead to considerable loss of skeletal muscle mass and strength. It has been speculated that such short, successive periods of muscle disuse may be largely responsible for the age-related loss of muscle mass throughout the lifespan.

Objective

To assess whether a single intramuscular injection of nandrolone decanoate prior to immobilization can attenuate the loss of muscle mass and strength in vivo in humans.

Design, setting and participants

Thirty healthy (22 ± 1 years) men were subjected to 7 days of one-legged knee immobilization by means of a full leg cast with (NAD, n = 15) or without (CON, n = 15) prior intramuscular nandrolone decanoate injection (200 mg).

Measures

SUBMITTER: Horstman AMH 

PROVIDER: S-EPMC6349315 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature