Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms.

ABSTRACT:

Background

It is known that local tissue injuries incurred by snakebites are quickly instilled causing extensive, irreversible, tissue destruction that may include loss of limb function or even amputation. Such injuries are not completely neutralized by the available antivenins, which in general are focused on halting systemic effects. Therefore it is prudent to investigate the potential antiophidic effects of natural and synthetic compounds, perhaps combining them with serum therapy, to potentially attenuate or eliminate the adverse local and systemic effects of snake venom. This study assessed a group of quinones that are widely distributed in nature and constitute an important class of natural products that exhibit a range of biological activities. Of these quinones, lapachol is

SUBMITTER: Strauch MA 

PROVIDER: S-EPMC6349327 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature