Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease.

ABSTRACT: Cell-adhesion glycoprotein neuroplastin (Np) is involved in the regulation of synaptic plasticity and balancing hippocampal excitatory/inhibitory inputs which aids in the process of associative memory formation and learning. Our recent findings show that neuroplastin expression in the adult human hippocampus is specifically associated with major hippocampal excitatory pathways and is related to neuronal calcium regulation. Here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (Np65), its relationship with amyloid and tau pathology in Alzheimer's disease (AD), and potential involvement of neuroplastin in tissue response during the disease progression. Np65 expression and localization was analysed in six human hippocampi with confirmed AD neuropathology, and

SUBMITTER: Ilic K 

PROVIDER: S-EPMC6349345 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature