Dysregulation and restoration of homeostatic network plasticity in fragile X syndrome mice.

ABSTRACT: Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain unclear. In the current study, we utilized a multielectrode array (MEA) recording system to evaluate homeostatic neural network activity of primary mouse cortical neuron cultures. We demonstrated that chronic elevation of neuronal activity through the inhibition of GABA(A) receptors elicits synchronization of neural network activity and homeostatic reduction of the amplitude of spontaneous neural network spikes. We subsequently showed that this phenomenon is mediated by the ubiq

SUBMITTER: Jewett KA 

PROVIDER: S-EPMC6349417 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature