Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility.

ABSTRACT: The role of AnxA6 in breast cancer and in particular, the mechanisms underlying its contribution to tumor cell growth and/or motility remain poorly understood. In this study, we established the tumor suppressor function of AnxA6 in triple negative breast cancer (TNBC) cells by showing that loss of AnxA6 is associated with early onset and rapid growth of xenograft TNBC tumors in mice. We also identified the Ca²⁺ activated RasGRF2 as an effector of AnxA6 mediated TNBC cell growth and motility. Activation of Ca²⁺ mobilizing oncogenic receptors such as epidermal growth factor receptor (EGFR) in TNBC cells or pharmacological stimulation of Ca²⁺ influx led to activation, subsequent degradation and altered effector functions of RasGRF2. Inhibition of Ca²⁺

SUBMITTER: Whalen DS 

PROVIDER: S-EPMC6349432 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature