Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo.

ABSTRACT: Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC₅₀, eribulin induced cell cycle arrest and apoptosis in a metastatic osteosarcoma cell line, LM8. However, at concentrations 50, (low dose), eribulin changed cell morphology and decreased LM8 migration. Low eribulin concentrations also reduced directionality during migration, peripheral localization of adenomatous polyposis coli protein, and turn

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC6349434 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature