Analysis of pituitary adenoma expression patterns suggests a potential role for the NeuroD1 transcription factor in neuroendocrine tumor-targeting therapies.

ABSTRACT: NeuroD1's roles in the pathogenesis of pituitary adenomas and in the biology of the normal adult pituitary gland have been insufficiently researched. Much of the work investigating its expression patterns has yielded contradictory results.

Objective

morphological study of NeuroD1 transcription factor expression in different types of pituitary adenomas and in normal adult human pituitary glands.

Materials and methods

This study analyzed 48 pituitary adenomas and nine normal pituitary glands. In all cases, immunohistochemical study was performed with antibodies to NeuroD1, 6 hormones of adenohypophysis, Ki-67, and CK7. We used confocal laser scanning microscopy, electron microscopy and electron immunocytochemistry.

Results

NeuroD1 expression was detected in all cases of

SUBMITTER: Mitrofanova LB 

PROVIDER: S-EPMC6349459 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature