Longitudinal Standards for Mid-life Cognitive Performance: Identifying Abnormal Within-Person Changes in the Wisconsin Registry for Alzheimer's Prevention.

ABSTRACT:

Objectives

A major challenge in cognitive aging is differentiating preclinical disease-related cognitive decline from changes associated with normal aging. Neuropsychological test authors typically publish single time-point norms, referred to here as unconditional reference values. However, detecting significant change requires longitudinal, or conditional reference values, created by modeling cognition as a function of prior performance. Our objectives were to create, depict, and examine preliminary validity of unconditional and conditional reference values for ages 40-75 years on neuropsychological tests.

Method

We used quantile regression to create growth-curve-like models of performance on tests of memory and executive function using participants from the Wisconsin Regis

SUBMITTER: Koscik RL 

PROVIDER: S-EPMC6349483 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature