A Multi-Institutional Experience of MR-Guided Liver Stereotactic Body Radiation Therapy.

ABSTRACT:

Purpose

Daily magnetic resonance (MR)-guided radiation has the potential to improve stereotactic body radiation therapy (SBRT) for tumors of the liver. Magnetic resonance imaging (MRI) introduces unique variables that are untested clinically: electron return effect, MRI geometric distortion, MRI to radiation therapy isocenter uncertainty, multileaf collimator position error, and uncertainties with voxel size and tracking. All could lead to increased toxicity and/or local recurrences with SBRT. In this multi-institutional study, we hypothesized that direct visualization provided by MR guidance could allow the use of small treatment volumes to spare normal tissues while maintaining clinical outcomes despite the aforementioned uncertainties in MR-guided treatment.

Methods and mater

SUBMITTER: Rosenberg SA 

PROVIDER: S-EPMC6349638 | biostudies-literature | 2019 Jan-Mar

REPOSITORIES: biostudies-literature