Visible light-induced direct α C-H functionalization of alcohols.

ABSTRACT: Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C-H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroarenes without the external photocatalysis, achieving the selective α sp³ C-H arylation of alcohol, even in the presence of ether. The N-F activation of selectfluor under blue LEDs irradiation is evidenced by electron paramagnetic resonance (EPR) study, which is the key process for the oxidative activation of α sp³ C-H alcohols. The observed reactivity may have significant implications for chemical transformations.

SUBMITTER: Niu L 

PROVIDER: S-EPMC6349847 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature