Retrieval of retrained and reconsolidated memories are associated with a distinct neural network.

ABSTRACT: Consolidated memories can persist from a single day to years, and persistence is improved by retraining or retrieval-mediated plasticity. One retrieval-based way to strengthen memory is the reconsolidation process. Strengthening occurs simply by the presentation of specific cues associated with the original learning. This enhancement function has a fundamental role in the maintenance of memory relevance in animals everyday life. In the present study, we made a step forward in the identification of brain correlates imprinted by the reconsolidation process studying the long-term neural consequences when the strengthened memory is stable again. To reach such a goal, we compared the retention of paired-associate memories that went through retraining process or were labilizated-reconsolidated.

SUBMITTER: Bavassi L 

PROVIDER: S-EPMC6349866 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature