Plasma coenzyme Q₁₀ status is impaired in selected genetic conditions.

ABSTRACT: Identifying diseases displaying chronic low plasma Coenzyme Q₁₀ (CoQ) values may be important to prevent possible cardiovascular dysfunction. The aim of this study was to retrospectively evaluate plasma CoQ concentrations in a large cohort of pediatric and young adult patients. We evaluated plasma CoQ values in 597 individuals (age range 1 month to 43 years, average 11 years), studied during the period 2005-2016. Patients were classified into 6 different groups: control group of healthy participants, phenylketonuric patients (PKU), patients with mucopolysaccharidoses (MPS), patients with other inborn errors of metabolism (IEM), patients with neurogenetic diseases, and individuals with neurological diseases with no genetic diagnosis. Plasma total CoQ was measured by reverse-phase

SUBMITTER: Montero R 

PROVIDER: S-EPMC6349877 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature