Adiposity in relation to risks of fatty liver, cirrhosis and liver cancer: a prospective study of 0.5 million Chinese adults.

ABSTRACT: Adiposity is an increasing public health problem in China. We aimed to examine the associations of adiposity with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases in Chinese adults. The prospective China Kadoorie Biobank recruited 512,891 adults aged 30-79 years from 10 areas. During 10 years of follow-up, 7,386 incident liver disease cases were recorded among 503,991 participants without prior cancer or chronic liver disease at baseline. The mean body mass index (BMI) (SD) was 23.7 (3.3) kg/m² and mean waist circumference (WC) 80.3 (9.8) cm, with 33% having BMI ≥25 kg/m². Throughout the range examined (BMI 15-50) BMI showed a log-linear positive association with NAFLD (n = 1,298), with adjusted HR per 5 kg/m² of 2.81 (95% CI 2.63-

SUBMITTER: Pang Y 

PROVIDER: S-EPMC6349919 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature