Hierarchical composition of reliable recombinase logic devices.
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ABSTRACT:
SUBMITTER: Guiziou S
PROVIDER: S-EPMC6349923 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Hierarchical composition of reliable recombinase logic devices.
Guiziou Sarah S Mayonove Pauline P Bonnet Jerome J
Nature communications 20190128 1
A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability and requiring time-consuming optimization. Here we provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, ...[more]
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