Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease.

ABSTRACT: Premature immune ageing, including thymic atrophy, is observed in patients with chronic kidney disease (CKD). Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), which are mineral and bone disorder (MBD)-related factors, affect immune cells and possibly cause thymic atrophy. We examined the cross-sectional association between thymic atrophy, evaluated as the number of CD3⁺CD4⁺CD45RA⁺CD31⁺ cells [recent thymic emigrants (RTE)/μL], and MBD-related factors [(serum PTH, FGF23, and alkaline phosphatase (ALP) level] in 125 patients with non-dialysis dependent CKD. Median estimated glomerular filtration rate (eGFR) was 17 mL/min/1.73 m². Older age (r = -0.46), male sex (r = -0.34), lower eGFR (r = 0.27), lower serum-corrected c

SUBMITTER: Iio K 

PROVIDER: S-EPMC6349929 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature