Quantitative Analysis of the Correlation between Cell Size and Cellular Uptake of Particles.

ABSTRACT: The size of a cell is central to many functions, including cellular communication and exchange of materials with the environment. This modeling and experimental study focused on understanding how the size of a cell determines its ability to uptake nanometer-scale extracellular materials from the environment. Several mechanisms in the cell plasma membrane mediate cellular uptake of nutrients, biomolecules, and particles. These mechanisms involve recognition and internalization of the extracellular molecules via endocytic components, such as clathrin-coated pits, vacuoles, and micropinocytic vesicles. Because the demand for an external resource could be different for cells of different sizes, the collective actions of these various endocytic routes should also vary based on the cell size. He

SUBMITTER: Khetan J 

PROVIDER: S-EPMC6349962 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature