Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.

ABSTRACT: Collecting sufficient quantities of primary neural crest cells (NCCs) for experiments is difficult, as NCCs are embryonic transient tissue that basically does not proliferate. We successfully induced NCCs from human induced pluripotent stem cells (iPSCs) in accordance with a previously described method with some modifications. The protocol used in this study efficiently produced large amounts of iPSC-derived NCCs (iPSC-NCCs). Many researchers have recently produced large amounts of iPSC-NCCs and used these to examine the physiological properties, such as migratory activity, and the potential for medical uses such as wound healing. Immunological properties of NCCs are yet to be reported. Therefore, the purpose of this study was to assess the immunological properties of human iPSC-NCCs. Our

SUBMITTER: Fujii S 

PROVIDER: S-EPMC6350061 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature