Development of an Initial Conceptual Model of Multiple Myeloma to Support Clinical and Health Economics Decision Making.

ABSTRACT: Background. We aimed to develop and validate a conceptual model of multiple myeloma (MM) that characterizes the attributes affecting disease progression and patient outcomes, and the relationships between them. Methods. Systematic and targeted literature reviews identified disease- and patient-specific attributes of MM that affect disease progression and outcomes. These attributes were validated by a Delphi panel of four international MM experts, and a physician-validated model was constructed. Real-world clinical data from the Czech Registry of Monoclonal Gammopathies (RMG) was used to confirm the relationships between attributes using pairwise correlations and multiple Cox regression analysis. Results. The Delphi panel reached consensus that most cytogenetic abnormalities influenced dise

SUBMITTER: Gonzalez-McQuire S 

PROVIDER: S-EPMC6350154 | biostudies-literature | 2019 Jan-Jun

REPOSITORIES: biostudies-literature