Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma.

Methods

Immunohistochemistry and western blotting were used to detect the expression of FN and αvβ3 in 60 osteosarcoma specimens and in 30 osteochondroma specimens. Furthermore, correlations of FN and αvβ3 with the clinicopathological features of osteosarcoma patients were analyzed using the χ² test and Fisher's exact test. Disease-free survival and overall survival of osteosarco

SUBMITTER: Shi K 

PROVIDER: S-EPMC6350278 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature