Expression profile of microRNAs in porcine alveolar macrophages after Toxoplasma gondii infection.

ABSTRACT:

Background

Toxoplasma gondii is an apicomplexan protozoan parasite that can cause serious clinical illnesses in both humans and animals. microRNAs (miRNAs) are non-protein-coding RNAs that can regulate the expression of target genes. A previous study found that many miRNAs were differentially expressed after T. gondii infection and exert significant effects and revealed that both host survival and the virulence of different strains can be regulated by different miRNAs. Macrophages play an important role in T. gondii infection, but few studies have investigated the relationship between miRNAs and porcine alveolar macrophages infected with T. gondii.

Methods

Porcine alveolar macrophages (3D4-21) were infected with the RH (Type I) and Me49 (Type II) strains of T. gondii for 12

SUBMITTER: Li S 

PROVIDER: S-EPMC6350279 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature