Ulcerative colitis: functional analysis of the in-depth proteome.

ABSTRACT:

Background

Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathophysiological features in UC from proteomics data.

Methods

Colon mucosa biopsies from inflamed tissue of untreated UC patients at diagnosis and from healthy controls were obtained during colonoscopy. Quantitative protein data was acquired by bottom-up proteomics and furthermore processed with MaxQuant. The quantitative proteome data was analyzed with Perseus and enrichment data was analyzed by ClueGO for Cytoscape.

Results

The generated proteome dataset is to-date the deepest from colon mucosa biopsies with 8562 identified proteins whereof 6818 were qua

SUBMITTER: Schniers A 

PROVIDER: S-EPMC6350310 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature