Does artemether-lumefantrine administration affect mosquito olfactory behaviour and fitness?

ABSTRACT:

Background

Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT and transmission to mosquitoes is still possible. Artemether-lumefantrine (AL) is a broadly used artemisinin-based combination medicine. Here, it is tested whether AL influences behaviour and fitness of Anopheles mosquitoes, which are the main vectors of P. falciparum.

Results

Dual-choice olfactometer and screenhouse experiments showed that skin odour of healthy human individuals obtained before, during and after AL-administration was equally attractive to Anopheles coluzzii and Anopheles gambiae sensu stricto, apart from a small (but significant) increas

SUBMITTER: de Boer JG 

PROVIDER: S-EPMC6350316 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature