Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

ABSTRACT:

Background

The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59).

Method

To study the genetic contribution to exclusive pediatric onset UC, a GWAS was performed on 466 cases with 2099 healthy controls using UK Biobank array. SNP2HLA was used to impute classical HLA alleles and their corresponding amino acids, and the results are compared with adult onset UC.

Results

HLA explained the almost entire association signal, dominated with

SUBMITTER: Venkateswaran S 

PROVIDER: S-EPMC6350448 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature