Systematic review with meta-analysis: proximal disease extension in limited ulcerative colitis.

ABSTRACT:

Background

Disease extent in ulcerative colitis is one of the major factors determining prognosis over the long-term. Disease extent is dynamic and a proportion of patients presenting with limited disease progress to more extensive forms of disease over time.

Aim

To perform a systematic review and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis.

Methods

We performed a systematic literature search to identify studies on disease extension of ulcerative colitis (UC) and predictors of disease progression.

Results

Overall, 41 studies were eligible for systematic review but only 30 for meta-analysis. The overall pooled frequency o

SUBMITTER: Roda G 

PROVIDER: S-EPMC6350510 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature