Impact of human milk on the transcriptomic response of fetal intestinal epithelial cells reveals expression changes of immune-related genes.

ABSTRACT: Human milk, the best food for infants, is a dynamic and complex fluid that directly influences the immune system and microbiota establishment. The protective role of human milk is well known although the mechanisms behind it still need to be uncovered. This study aimed to characterize the impact of human milk in the immature intestine of newborns by analyzing the global transcriptomic response of the FHs 74 int cell line (ATCC CCL-241). The expression of intestinal keratins and other genes with a well-annotated intestinal or epithelial function validated FHs 74 int derived from the fetal small intestine as a model of the intestinal epithelium of newborns. Cells exposed to skimmed human milk showed seventeen differentially expressed genes, most of them up-regulated, including four chemokine

SUBMITTER: Gimeno-Alcaniz JV 

PROVIDER: S-EPMC6350622 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature