Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials.

ABSTRACT:

Background

Previous clinical studies reported inconsistent results on the associations of statins with the mortality and survival of lung cancer patients. This review and meta-analysis summarized the impact of statins on mortality and survival of lung cancer patients.

Materials and methods

Eligible papers of this meta-analysis were searched by using PubMed, EMBASE, and Cochrane until July 2017. Primary end points were the mortality (all-cause mortality and cancer-specific mortality) and survival (progression-free survival and overall survival) of patients with statin use. Secondary end points were overall response rate and safety. The random-effects model was used to calculate pooled HRs and 95% CIs.

Results

Seventeen studies involving 98,445 patients were included in

SUBMITTER: Xia DK 

PROVIDER: S-EPMC6350654 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature