A non-functional neoepitope specific CD8⁺ T-cell response induced by tumor derived antigen exposure in vivo.

ABSTRACT: Cancer-associated mutations, mostly single nucleotide variations, can act as neoepitopes and prime targets for effective anti-cancer T-cell immunity. T cells recognizing cancer mutations are critical for the clinical activity of immune checkpoint blockade (ICB) and they are potent vaccine antigens. High frequencies of mutation-specific T cells are rarely spontaneously induced. Hence, therapies that broaden the tumor specific T-cell response are of interest. Here, we analyzed neoepitope-specific CD8⁺ T-cell responses mounted either spontaneously or after immunotherapy regimens, which induce local tumor inflammation and cell death, in mice bearing tumors of the widely used colon carcinoma cell line CT26. A comprehensive immune reactivity screening of 2474 peptides covering 628 tra

SUBMITTER: Vormehr M 

PROVIDER: S-EPMC6350691 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature