Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction.

ABSTRACT:

Background and aims

Variation in micro-RNA (miRNA) levels in blood has been associated with alterations of physiological functions of the cardiovascular system. Circulating miRNA have the potential to become reliable biomarkers for risk stratification and early detection of cardiovascular events. Recurrent thrombotic events in patients with established coronary artery disease (CAD) demonstrate the need for personalized approaches to secondary prevention, especially in light of recent novel treatment approaches.

Methods

In a single center cohort study, whole blood samples were collected from 437 subjects undergoing cardiac catheterization, who were followed for recurrent cardiovascular events during a mean follow up of 1.5 years. We selected a case cohort (n = 22) with recurr

SUBMITTER: Kanuri SH 

PROVIDER: S-EPMC6350783 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature