Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples.

ABSTRACT:

Background

Etiologies of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are heterogeneous. We phenotyped severe AECOPD based on molecular pathogen detection of sputum samples collected at hospitalization of COPD patients and determined their outcomes.

Methods

We phenotyped 72 sputum samples of COPD patients who were hospitalized with a primary diagnosis of AECOPD using a molecular array that detected common bacterial and viral respiratory pathogens. Based on these results, the patients were classified into positive or negative pathogen groups. The pathogen-positive group was further divided into virus or bacteria subgroups. Admission day 1 blood samples were assayed for N-terminal prohormone brain natriuretic peptide, CRP, and complete blood counts.

SUBMITTER: Alotaibi NM 

PROVIDER: S-EPMC6350828 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature