Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach.

ABSTRACT:

Purpose

Multiple myeloma (MM) is a malignancy of plasma cells, with a median survival of 6 years. Despite recent therapeutic advancements, relapse remains mostly inevitable, and the disease is fatal in the majority of patients. A major challenge in the treatment of patients with relapsed MM is the timely identification of treatment options in a personalized manner. Current approaches in precision oncology aim at matching specific DNA mutations to drugs, but incorporation of genome-wide RNA profiles has not yet been clinically assessed.

Methods

We have developed a novel computational platform for precision medicine of relapsed and/or refractory MM on the basis of DNA and RNA sequencing. Our approach expands on the traditional DNA-based approaches by integrating somatic mutati

SUBMITTER: Lagana A 

PROVIDER: S-EPMC6350920 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature