Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study.

ABSTRACT: Meningeal inflammation and encapsulation of neural electrode arrays is a leading cause of device failure, yet little is known about how it develops over time or what triggers it. This work characterizes the dynamic changes of meningeal inflammatory cells and collagen-I in order to understand the meningeal tissue response to neural electrode implantation. We use in vivo two-photon microscopy of CX3CR1-GFP mice over the first month after electrode implantation to quantify changes in inflammatory cell behavior as well as meningeal collagen-I remodeling. We define a migratory window during the first day after electrode implantation hallmarked by robust inflammatory cell migration along electrodes in the meninges as well as cell trafficking through meningeal venules. This migratory window atten

SUBMITTER: Eles JR 

PROVIDER: S-EPMC6350934 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature