Thrombocytopenia Impairs Host Defense Against Burkholderia pseudomallei (Melioidosis).

ABSTRACT:

Background

Infection with the gram-negative bacillus Burkholderia pseudomallei (melioidosis) is an important cause of pneumosepsis in Southeast Asia and has a mortality of up to 40%. We aimed to assess the role of platelets in the host response against B. pseudomallei infection.

Methods

Association between platelet counts and mortality was determined in 1160 patients with culture-proven melioidosis. Mice treated with (low- or high-dose) platelet-depleting antibody were inoculated intranasally with B. pseudomallei and killed. Additional studies using functional glycoprotein Ibα-deficient mice were conducted.

Results

Thrombocytopenia was present in 31% of patients at admission and predicted mortality in melioidosis patients even after adjustment for confounders. In our

SUBMITTER: Birnie E 

PROVIDER: S-EPMC6350952 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature