Golgin-160 and GMAP210 play an important role in U251 cells migration and invasion initiated by GDNF.

ABSTRACT: Gliomas are the most common malignant tumors of the brain and are characteristic of severe migration and invasion. Glial cell line-derived neurotrophic factor (GDNF) promotes glioma development process. However, the regulatory mechanisms of promoting occurrence and development of glioma have not yet been clearly elucidated. In the present study, the mechanism by which GDNF promotes glioma cell migration and invasion through regulating the dispersion and location of the Golgi apparatus (GA) is described. Following GDNF treatment, a change in the volume and position of GA was observed. The stack area of the GA was enlarged and it was more concentrated near the nucleus. Golgin-160 and Golgi microtubule-associated protein 210 (GMAP210) were identified as target molecules regulating GA position

SUBMITTER: Tang CX 

PROVIDER: S-EPMC6351060 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature