Mitofusin1 in oocyte is essential for female fertility.

ABSTRACT: Mitofusins (Mfn) are the important regulators of mitochondrial organization in mammalian cells; however, their roles during oocyte development remain unknown. In the present study, we generated mice with oocyte-specific knockout of Mfn1 or Mfn2 (Mfn1^fl/fl;Zp3-Cre or Mfn2^fl/fl;Zp3-Cre). We report that deletion of Mfn1, but not Mfn2, in oocytes leads to female mice sterility, associated with the defective folliculogenesis and impaired oocyte quality. In specific, follicles are arrested at secondary stage in Mfn1^fl/fl;Zp3-Cre mice, accompanying with the reduced proliferation of granulosa cells. Moreover, alterations of mitochondrial structure and distribution pattern are readily observed in Mfn1-null oocytes. Consistent with this, mitochondrial activity and fu

SUBMITTER: Hou X 

PROVIDER: S-EPMC6351231 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature