Investigation of the changes in the expression levels of MOZ gene in colorectal cancer tissues.

ABSTRACT:

Background

MOZ is one of the most important histone acetyltransferases (HATs) that has an effective role in gene expression. It is an important partner in chromosomal rearrangement that usually occurs in hematological malignancies such as leukemia. Besides these malignancies, its role in solid tumors has been reported. In the present study, we aimed to quantify of MOZ messenger RNA (mRNA) expression in colorectal cancer (CRC) tissues from a northwest population of Iran and consequently to assess the effect of MOZ in CRC.

Methods

Tumorous and adjacent non-tumorous tissues recruited from 26 patients with CRC. mRNA extraction and complementary DNA (cDNA) synthesis were performed from these tissues, at the next step quantitative real-time reverse-transcription polymerase chain r

SUBMITTER: Mohammadi K 

PROVIDER: S-EPMC6351307 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature