The Contribution of Various MRI Parameters to Clinical and Cognitive Disability in Multiple Sclerosis.

ABSTRACT: Next to the disseminated clinical symptoms, cognitive dysfunctions are common features of multiple sclerosis (MS). Over the recent years several different MRI measures became available representing the various features of the pathology, but the contribution to various clinical and cognitive functions is not yet fully understood. In this multiparametric MRI study we set out to identify the set of parameters that best predict the clinical and cognitive disability in MS. High resolution T1 weighted structural and high angular resolution diffusion MRI images were measured in 53 patients with relapsing remitting MS and 53 healthy controls. Clinical disability was inflicted by EDSS and cognitive functions were evaluated with the BICAMS tests. The contribution of lesion load, partial brain, white

SUBMITTER: Toth E 

PROVIDER: S-EPMC6351478 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature