The Importance of Therapeutic Time Window in the Treatment of Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) is a major cause of death and disability. Despite its importance in public health, there are presently no drugs to treat TBI. Many reasons underlie why drugs have failed clinical trials, one reason is that most drugs to treat TBI lose much of their efficacy before patients are first treated. This review discusses the importance of therapeutic time window; the time interval between TBI onset and the initiation of treatment. Therapeutic time window is complex, as brain injury is both acute and chronic, resulting in multiple drug targets that appear and disappear with differing kinetics. The speed and increasing complexity of TBI pathophysiology is a major reason why drugs lose efficacy as time to first dose increases. Recent Phase III clinical trials treated mode

SUBMITTER: Mohamadpour M 

PROVIDER: S-EPMC6351484 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature