Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children.

ABSTRACT: Young children are the population most severely affected by Plasmodium falciparum malaria. Seasonal malaria chemoprevention (SMC) with amodiaquine and sulfadoxine-pyrimethamine provides substantial benefit to this vulnerable population, but resistance to the drugs will develop. Here, we evaluate the use of dihydroartemisinin-piperaquine as an alternative regimen in 179 children (aged 2.33-58.1 months). Allometrically scaled body weight on pharmacokinetic parameters of piperaquine result in lower drug exposures in small children after a standard mg per kg dosage. A covariate-free sigmoidal E_MAX-model describes the interval to malaria re-infections satisfactorily. Population-based simulations suggest that small children would benefit from a higher dosage according to the WHO 2015

SUBMITTER: Chotsiri P 

PROVIDER: S-EPMC6351525 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature