DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions.

ABSTRACT: A consistent gene set undergoes age-associated expression changes in the human cerebral cortex, and our Age-by-Disease Model posits that these changes contribute to psychiatric diseases by "pushing" the expression of disease-associated genes in disease-promoting directions. DNA methylation (DNAm) is an attractive candidate mechanism for age-associated gene expression changes. We used the Illumina HumanMethylation450 array to characterize genome-wide DNAm in the postmortem orbital frontal cortex from 20 younger (<42 years) and 19 older (>60 years) subjects. DNAm data were integrated with existing normal brain aging expression data and sets of psychiatric disease risk genes to test the hypothesis that age-associated DNAm changes contribute to age-associated gene expression changes and, by ex

SUBMITTER: McKinney BC 

PROVIDER: S-EPMC6351569 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature