Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress.

ABSTRACT: The gut microbiota has been increasingly correlated with depressive disorder. It was recently shown that the transplantation of the gut microbiota from depressed patients to animals can produce depressive-like behaviors, suggesting that the gut microbiota plays a causal role in the development of depression. In addition, metabolic disorder, which is strongly associated with depression, is exacerbated by changes in the composition of the gut microbiota and is alleviated by treatment with antidepressants. However, the key players and pathways that link the gut microbiota to the pathogenesis of depression remain largely unknown. To evaluate the relationships between depression and metabolic disorders in feces and plasma, we monitored changes in fecal and plasma metabolomes during the developm

SUBMITTER: Jianguo L 

PROVIDER: S-EPMC6351597 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature