Urogenital schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents.

ABSTRACT: Urogenital schistosomiasis is a neglected tropical disease caused by the parasite Schistosoma haematobium, which resides in the vasculature surrounding the urogenital system. Previous work has suggested that helminthic infections can affect the intestinal microbiome, and we hypothesized that S. haematobium infection could result in an alteration of immune system-microbiota homeostasis and impact the composition of the gut microbiota. To address this question, we compared the fecal microbiomes of infected and uninfected schoolchildren from the Argungu Local Government Area of Kebbi State, Nigeria, detecting significant differences in community composition between the two groups. Most remarkably, we observed a decreased abundance of Firmicutes and increased abundance of Proteobacteria - a sh

SUBMITTER: Ajibola O 

PROVIDER: S-EPMC6351658 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature