Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.

ABSTRACT: Frontotemporal dementia refers to a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins. The effects of these proteins in the brain are complex, and each can present with several different clinical syndromes. Clinical efficacy trials of drugs targeting these proteins must use endpoints that are meaningful to all participants despite the variability in symptoms across patients. There are many candidate clinical measures, including neuropsychological scores and functional measures. Brain imaging is another potentially attractive outcome that can be precisely quantified and provides evidence of disease modification. Most imaging studies in frontotemporal dementia have been cross-sectional, and few have compared longitudina

SUBMITTER: Staffaroni AM 

PROVIDER: S-EPMC6351779 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature