Independent associations of TOMM40 and APOE variants with body mass index.

ABSTRACT: The TOMM40-APOE variants are known for their strong, antagonistic associations with Alzheimer's disease and body weight. While a stronger role of the APOE than TOMM40 variants in Alzheimer's disease was suggested, comparative contribution of the TOMM40-APOE variants in the regulation of body weight remains elusive. We examined additive effects of rs2075650 and rs157580 TOMM40 variants and rs429358 and rs7412 APOE variants coding the ε2/ε3/ε4 polymorphism on body mass index (BMI) in age-aggregated and age-stratified cohort-specific and cohort-pooled analysis of 27,863 Caucasians aged 20-100 years from seven longitudinal studies. Minor alleles of rs2075650, rs429358, and rs7412 were individually associated with BMI (β = -1.29, p = 3.97 × 10^-9 ; β = -1.38, p = 2.78 × 10^-10

SUBMITTER: Kulminski AM 

PROVIDER: S-EPMC6351823 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature